Herpes labialis, commonly known as cold sores, remains a prevalent viral infection. Patients frequently seek rapid relief from symptoms. Topical antiviral agents are often prescribed for this purpose. Among these, acyclovir cream 5% stands out as a common choice. Understanding its role, efficacy, and application in treating herpes labialis becomes crucial in medical practice. This article explores these aspects while delving into the broader landscape of topical antiviral therapies. The Pharmacodynamics of Acyclovir Cream Acyclovir cream 5% operates by inhibiting viral DNA synthesis. This action restricts viral replication, effectively reducing the severity